Posts in category Genetics


Genetics

Many unexpected genetic variants hamper personalised medicine

In recent decades much hope was based on the development of personalised drug treatments, in which genetic tests determine the choice and optimal dose of medication for each individual patient. However, the real breakthrough is still to be seen, and now researchers at Karolinska Institutet show in two separate scientific papers that many more gene variants affect how a person responds to medication than previously thought – and thus that today’s analytical tools are too coarse.

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Genetics

Researchers elucidate network of genes that control when puberty begins

In expanding our knowledge of how the brain controls the process of sexual development, researchers at Oregon Healthy & Science University and the University of Pittsburgh have identified for the first time members of an elaborate superfamily of genes that regulate the timing of puberty in highly evolved nonhuman primates. The Zinc finger, or ZNF, gene family comprises approximately 800 individual genes.

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Genetics

Why treat gene editing differently in two types of human cells?

At the conclusion of the recent International Summit on Human Gene Editing in Washington, DC, its organizing committee released a much-anticipated statement recommending how human genetic engineering should be regulated. Co-organized by US, UK and Chinese national academies, the summit gathered preeminent researchers, clinicians and ethicists to grapple with how new gene editing technologies – particularly the method known as CRISPR – should be used. As CRISPR-cas9 is refined in the lab, several actual and proposed trials using the technique have raised ethical concerns.

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